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Eur J Radiol. 2014 May;83(5):848-57. doi: 10.1016/j.ejrad.2014.01.025. Epub 2014 Feb 7.

Influence of radiation dose and iterative reconstruction algorithms for measurement accuracy and reproducibility of pulmonary nodule volumetry: A phantom study.

Author information

1
Department of Radiology, Seoul National University College of Medicine, Institute of Radiation Medicine, Seoul National University Medical Research Center, 101, Daehangno, Jongno-gu, Seoul 110-744, Republic of Korea. Electronic address: khj.snuh@gmail.com.
2
Department of Radiology, Seoul National University College of Medicine, Institute of Radiation Medicine, Seoul National University Medical Research Center, 101, Daehangno, Jongno-gu, Seoul 110-744, Republic of Korea; Cancer Research Institute, Seoul National University, 101, Daehangno, Jongno-gu, Seoul 110-744, Republic of Korea. Electronic address: cmpark@radiol.snu.ac.kr.
3
Department of Radiology, Seoul National University College of Medicine, Institute of Radiation Medicine, Seoul National University Medical Research Center, 101, Daehangno, Jongno-gu, Seoul 110-744, Republic of Korea. Electronic address: terasong@gmail.com.
4
Department of Radiology, Seoul National University College of Medicine, Institute of Radiation Medicine, Seoul National University Medical Research Center, 101, Daehangno, Jongno-gu, Seoul 110-744, Republic of Korea. Electronic address: sangmin.lee.md@gmail.com.
5
Department of Radiology, Seoul National University College of Medicine, Institute of Radiation Medicine, Seoul National University Medical Research Center, 101, Daehangno, Jongno-gu, Seoul 110-744, Republic of Korea; Cancer Research Institute, Seoul National University, 101, Daehangno, Jongno-gu, Seoul 110-744, Republic of Korea. Electronic address: jmgoo@plaza.snu.ac.kr.

Abstract

PURPOSE:

To evaluate the influence of radiation dose settings and reconstruction algorithms on the measurement accuracy and reproducibility of semi-automated pulmonary nodule volumetry.

MATERIALS AND METHODS:

CT scans were performed on a chest phantom containing various nodules (10 and 12mm; +100, -630 and -800HU) at 120kVp with tube current-time settings of 10, 20, 50, and 100mAs. Each CT was reconstructed using filtered back projection (FBP), iDose(4) and iterative model reconstruction (IMR). Semi-automated volumetry was performed by two radiologists using commercial volumetry software for nodules at each CT dataset. Noise, contrast-to-noise ratio and signal-to-noise ratio of CT images were also obtained. The absolute percentage measurement errors and differences were then calculated for volume and mass. The influence of radiation dose and reconstruction algorithm on measurement accuracy, reproducibility and objective image quality metrics was analyzed using generalized estimating equations.

RESULTS:

Measurement accuracy and reproducibility of nodule volume and mass were not significantly associated with CT radiation dose settings or reconstruction algorithms (p>0.05). Objective image quality metrics of CT images were superior in IMR than in FBP or iDose(4) at all radiation dose settings (p<0.05).

CONCLUSION:

Semi-automated nodule volumetry can be applied to low- or ultralow-dose chest CT with usage of a novel iterative reconstruction algorithm without losing measurement accuracy and reproducibility.

KEYWORDS:

Computer-assisted image processing; Lung neoplasms; Multidetector computed tomography; Pulmonary nodule; Radiation dosage; Reproducibility of results

PMID:
24572380
DOI:
10.1016/j.ejrad.2014.01.025
[Indexed for MEDLINE]

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