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Med Sci (Paris). 2014 Feb;30(2):186-93. doi: 10.1051/medsci/20143002017. Epub 2014 Feb 24.

[Targeted genome modifications using TALEN].

[Article in French]

Author information

1
Inserm U908, université de Lille 1, bâtiment SN3, Cité scientifique, 59655 Villeneuve d'Ascq, France.
2
Inserm U908, université de Lille 1, bâtiment SN3, Cité scientifique, 59655 Villeneuve d'Ascq, France - Institut de recherche interdisciplinaire, CNRS USR 3078, parc scientifique de la Haute Borne, 50, avenue Halley, 59658 Villeneuve d'Ascq, France.

Abstract

Precise modifications of genomes have been one of the biggest goals in the fields of biotechnology and biomedical research. Recent discovery of TALE (transcription activator-like effectors) and the engineering of customized TALEN (transcription activator-like effector nucleases) allowed rapid genome editing in a variety of cell types and different model organisms. TALEN are molecular scissors used to induce a wide range of specific and efficient genomic modifications. TALEN promise to have profound impacts on biological and medical research over the coming years.

PMID:
24572118
DOI:
10.1051/medsci/20143002017
[Indexed for MEDLINE]
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