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MBio. 2014 Feb 25;5(2):e00884-14. doi: 10.1128/mBio.00884-14.

Middle East respiratory syndrome coronavirus infection in dromedary camels in Saudi Arabia.

Erratum in

  • MBio. 2014;5(2):e01002-14. Burbelo, Peter D [added].

Abstract

The Middle East respiratory syndrome (MERS) is proposed to be a zoonotic disease; however, the reservoir and mechanism for transmission of the causative agent, the MERS coronavirus, are unknown. Dromedary camels have been implicated through reports that some victims have been exposed to camels, camels in areas where the disease has emerged have antibodies to the virus, and viral sequences have been recovered from camels in association with outbreaks of the disease among humans. Nonetheless, whether camels mediate transmission to humans is unresolved. Here we provide evidence from a geographic and temporal survey of camels in the Kingdom of Saudi Arabia that MERS coronaviruses have been circulating in camels since at least 1992, are distributed countrywide, and can be phylogenetically classified into clades that correlate with outbreaks of the disease among humans. We found no evidence of infection in domestic sheep or domestic goats. IMPORTANCE This study was undertaken to determine the historical and current prevalence of Middle East respiratory syndrome (MERS) coronavirus infection in dromedary camels and other livestock in the Kingdom of Saudi Arabia, where the index case and the majority of cases of MERS have been reported.

PMID:
24570370
PMCID:
PMC3940034
DOI:
10.1128/mBio.00884-14
[Indexed for MEDLINE]
Free PMC Article

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