Plasma angiopoietin-1 is lower after ischemic stroke and associated with major disability but not stroke incidence

Stroke. 2014 Apr;45(4):1064-8. doi: 10.1161/STROKEAHA.113.004339. Epub 2014 Feb 25.

Abstract

Background and purpose: Studies in rodent models suggest that upregulating angiopoietin-1 (Angpt1) improves stroke outcomes. The aims of this study were to assess the association of plasma Angpt1 with stroke occurrence and outcome.

Methods: Plasma Angpt1 was measured in 336 patients who had experienced a recent stroke and 321 healthy controls with no stroke history. Patients with stroke (n=285) were reassessed at 3 months and plasma Angpt1 concentration on admission compared between those with severe and minor disability as assessed by the modified Rankin scale. In a separate cohort of 4032 community-acquired older men prospectively followed for a minimum of 6 years, the association of plasma Angpt1 with stroke incidence was examined.

Results: Median plasma Angpt1 was 3-fold lower in patients who had experienced a recent stroke (6.42, interquartile range, 4.26-9.53 compared with 17.36; interquartile range, 14.01-22.46 ng/mL; P<0.001) and remained associated with stroke after adjustment for other risk factors. Plasma Angpt1 concentrations on admission were lower in patients who had severe disability or died at 3 months (median, 5.52; interquartile range, 3.81-8.75 ng/mL for modified Rankin scale 3-6; n=91) compared with those with minor disability (median, 7.04; interquartile range, 4.75-9.92 ng/mL for modified Rankin scale 0-2; n=194), P=0.012, and remained negatively associated with severe disability or death after adjusting for other risk factors. Plasma Angpt1 was not predictive of stroke incidence in community-dwelling older men.

Conclusions: Plasma Angpt1 concentrations are low after ischemic stroke particularly in patients with poor stroke outcomes at 3 months. Interventions effective at upregulating Angpt1 could potentially improve stroke outcomes.

Keywords: angiopoietin-1; biological markers.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Angiopoietin-1 / blood*
  • Biomarkers / blood
  • Brain Ischemia / blood*
  • Brain Ischemia / classification
  • Brain Ischemia / mortality*
  • Case-Control Studies
  • Disability Evaluation*
  • Follow-Up Studies
  • Humans
  • Incidence
  • Male
  • Middle Aged
  • Predictive Value of Tests
  • Prospective Studies
  • Risk Factors
  • Severity of Illness Index
  • Stroke / blood*
  • Stroke / classification
  • Stroke / mortality*

Substances

  • ANGPT1 protein, human
  • Angiopoietin-1
  • Biomarkers