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Sci Rep. 2014 Feb 26;4:4202. doi: 10.1038/srep04202.

Stomach microbiota composition varies between patients with non-atrophic gastritis and patients with intestinal type of gastric cancer.

Author information

1
Unidad de Investigación en Enfermedades Infecciosas, Tubo Digestivo Alto, UMAE Oncologia.
2
Departamento de Sarcomas, Tubo Digestivo Alto, UMAE Oncologia.
3
Servicio de Patologia, UMAE Oncologia, Centro Medico Nacional SXXI, Mexico City.

Abstract

We aimed to characterize microbiota of the gastric mucosa as it progress to intestinal type of cancer. Study included five patients each of non-atrophic gastritis (NAG), intestinal metaplasia (IM) and intestinal-type gastric cancer (GC). Gastric tissue was obtained and DNA extracted for microbiota analyses using the microarray G3 PhyloChip. Bacterial diversity ranged from 8 to 57, and steadily decreased from NAG to IM to GC (p = 0.004). A significant microbiota difference was observed between NAG and GC based on Unifrac-presence/absence and weighted-Unifrac-abundance metrics of 283 taxa (p < 0.05). HC-AN analyses based on presence/absence of 238 taxa revealed that GC and NAG grouped apart, whereas IM overlapped with both. An ordinated analyses based on weighted-Unifrac distance given abundance of 44 taxa showing significance across categories revealed significant microbiota separation between NAG and GC. This study is the first to show a gradual shift in gastric microbiota profile from NAG to IM to GC.

PMID:
24569566
PMCID:
PMC3935187
DOI:
10.1038/srep04202
[Indexed for MEDLINE]
Free PMC Article

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