Abstract
Palmitoyl-CoA is shown here to inhibit the pH-dependent anion-conducting channel (IMAC) in the inner membrane of rat liver mitochondria, with half-maximal inhibition at 2.4 microM. It has little effect on the transport of ribose, thiocyanate and glutamate. Palmitic acid and palmitoyl-carnitine stimulate the entry of all the above metabolites. CoASH and carnitine have no effect on chloride uniport. Palmitoyl-CoA and the IMAC may have a role in controlling thermogenesis in liver mitochondria.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acyl Coenzyme A / pharmacology*
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Animals
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Anions / metabolism*
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Cells, Cultured
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Culture Media
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Dose-Response Relationship, Drug
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Hydrogen-Ion Concentration
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Intracellular Membranes / drug effects*
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Intracellular Membranes / metabolism
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Ion Channels / drug effects*
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Ion Channels / metabolism
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Mitochondria, Liver / drug effects*
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Mitochondria, Liver / metabolism
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Mitochondria, Liver / ultrastructure
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Palmitic Acids / pharmacology
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Palmitoyl Coenzyme A / pharmacology*
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Palmitoylcarnitine / pharmacology
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Rats
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Rats, Inbred Strains
Substances
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Acyl Coenzyme A
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Anions
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Culture Media
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Ion Channels
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Palmitic Acids
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Palmitoyl Coenzyme A
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Palmitoylcarnitine