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Nat Rev Endocrinol. 2014 May;10(5):253-5. doi: 10.1038/nrendo.2014.18. Epub 2014 Feb 25.

Diabetes. Solving human β-cell development--what does the mouse say?

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1
Diabetes Center, Department of Medicine, University of California-San Francisco, 513 Parnassus Avenue, HSW 1116, Box 0540, San Francisco, CA 94143, USA.

Abstract

A genetic analysis of patients with permanent neonatal diabetes mellitus has revealed functional conservation of transcription factors critical for β-cell development in both mouse and man. This finding supports the use of mice for modelling human disease but also highlights the need for additional human-specific studies of β-cell function.

PMID:
24566816
DOI:
10.1038/nrendo.2014.18
[Indexed for MEDLINE]
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