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Molecules. 2014 Feb 21;19(2):2469-80. doi: 10.3390/molecules19022469.

Novel lycorine derivatives as anticancer agents: synthesis and in vitro biological evaluation.

Author information

1
College of Pharmacy & State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China.
2
College of Life Sciences, Nankai University, Tianjin 300071, China.
3
College of Pharmacy & State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China. shanglq@nankai.edu.cn.
4
College of Pharmacy & State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China. zheng_yin@nankai.edu.cn.

Abstract

Lycorine, which is the most abundant alkaloid isolated from the Amaryllidaceae family of plants, reportedly exhibits promising anticancer activities. Herein, a series of novel lycorine derivatives were synthesized and evaluated for their in vitro inhibitory activities against seven different cancer cell lines, including A549, HCT116, SK-OV-3, NCI-H460, K562, MCF-7 and HL-60. The results indicated that compounds bearing diverse amine substituents at the C-2 position demonstrated good anticancer activities. The selectivity towards different cancer cell lines of the synthesized derivatives is discussed.

PMID:
24566315
DOI:
10.3390/molecules19022469
[Indexed for MEDLINE]
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