Format

Send to

Choose Destination
Trends Immunol. 2014 Apr;35(4):144-52. doi: 10.1016/j.it.2014.01.002. Epub 2014 Feb 21.

Re-examining class-I presentation and the DRiP hypothesis.

Author information

1
Department of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts, USA. Electronic address: Kenneth.Rock@umassmed.edu.
2
Department of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
3
Department of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts, USA. Electronic address: jeff.colbert@umassmed.edu.
4
Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.

Abstract

MHC class I molecules present peptides derived from intracellular proteins, enabling immune surveillance by CD8(+) T cells and the elimination of virus-infected and cancerous cells. It has been argued that the dominant source of MHC class I-presented peptides is through proteasomal degradation of newly synthesized defective proteins, termed defective ribosomal products (DRiPs). Here, we critically examine the DRiP hypothesis and discuss recent studies indicating that antigenic peptides are generated from the entire proteome and not just from failures in protein synthesis or folding.

KEYWORDS:

MHC class I; antigen presentation; defective ribosomal product; proteasome

PMID:
24566257
PMCID:
PMC3986829
DOI:
10.1016/j.it.2014.01.002
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center