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Antimicrob Agents Chemother. 2014 May;58(5):2958-60. doi: 10.1128/AAC.02341-13. Epub 2014 Feb 24.

Complete nucleotide sequences of two blaKPC-2-bearing IncN Plasmids isolated from sequence type 442 Klebsiella pneumoniae clinical strains four years apart.

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1
Centro de Inovações Tecnológicas do Instituto Evandro Chagas/SVS/Ministério da Saúde, Ananindeua, Pará, Brazil.

Abstract

We sequenced the oldest blaKPC-2-bearing plasmid isolated in Brazil and another plasmid also carried by a Klebsiella pneumoniae strain of sequence type 442 (ST442), isolated 52 months later. Both plasmids present an IncN backbone and few acquired regions. Because the 2005 plasmid presented deletions and a truncated gene within Tn4401b compared to the 2009 plasmid, we can thus infer that IncN blaKPC-2-bearing plasmids pFCF1305 and pFCF3SP had a common ancestor circulating in Brazil prior to May 2005.

PMID:
24566176
PMCID:
PMC3993209
DOI:
10.1128/AAC.02341-13
[Indexed for MEDLINE]
Free PMC Article
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