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Eur J Cancer Prev. 2015 Jan;24(1):16-23. doi: 10.1097/CEJ.0000000000000017.

The stomach cancer pooling (StoP) project: study design and presentation.

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1
aDepartment of Epidemiology, IRCCS - Istituto di Ricerche Farmacologiche Mario Negri bDepartment of Clinical Sciences and Community Health, University of Milan, Milan cSection of Hygiene, Institute of Public Health, Università Cattolica del Sacro Cuore dIRCCS San Raffaele Pisana, Rome, Italy eInstitute of Public Health, University of Porto (ISPUP) fDepartment of Clinical Epidemiology, Predictive Medicine and Public Health, University of Porto Medical School, Porto, Portugal gDepartment of Epidemiology, UCLA Fielding School of Public Health and Jonsson Comprehensive Cancer Center, Los Angeles, California hThe Tisch Cancer Institute and Institute for Translational Epidemiology, Mount Sinai School of Medicine, New York iMemorial Sloan Kettering Cancer Centre, Rockville Centre jDepartment of Social and Preventive Medicine, School of Public Health and Health Professions, University of Buffalo, Buffalo, New York kDepartment of Epidemiology, Harvard School of Public Health, Boston, Massachusetts lPenn State College of Medicine, Hershey, Pennsylvania, USA mCancer Epidemiology Unit, Institute of Social and Preventive Medicine (IUMSP), Lausanne University Hospital, Lausanne, Switzerland nDepartment of Preventive Medicine, Kyushu University Faculty of Medical Sciences, Fukuoka oDivision of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan pScience Integration Division, Social Determinants and Science Integration Directorate, Public Health Agency of Canada qDepartment of Epidemiology and Community Health, University of Ottawa, Ottawa, Ontario rAboriginal and Global Health Research Group, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada sDigestive Oncology Research Center, Digestive Disease Research Institute, Tehran Universities of Medical Sciences, Tehran tDepartment of Community Medicine, Ardabil University of Medical Sciences, Ardabil, Iran uInstitute of Cardiovascular & Medical Sciences, University of Glasgow, Glasgo

Abstract

Gastric cancer affects about one million people per year worldwide, being the second leading cause of cancer mortality. The study of its etiology remains therefore a global issue as it may allow the identification of major targets, besides eradication of Helicobacter pylori infection, for primary prevention. It has however received little attention, given its comparatively low incidence in most high-income countries. We introduce a consortium of epidemiological investigations named the 'Stomach cancer Pooling (StoP) Project'. Twenty-two studies agreed to participate, for a total of over 9000 cases and 23 000 controls. Twenty studies have already shared the original data set. Of the patients, 40% are from Asia, 43% from Europe, and 17% from North America; 34% are women and 66% men; the median age is 61 years; 56% are from population-based case-control studies, 41% from hospital-based ones, and 3% from nested case-control studies derived from cohort investigations. Biological samples are available from 12 studies. The aim of the StoP Project is to analyze the role of lifestyle and genetic determinants in the etiology of gastric cancer through pooled analyses of individual-level data. The uniquely large data set will allow us to define and quantify the main effects of each risk factor of interest, including a number of infrequent habits, and to adequately address associations in subgroups of the population, as well as interaction within and between environmental and genetic factors. Further, we will carry out separate analyses according to different histotypes and subsites of gastric cancer, to identify potential different risk patterns and etiological characteristics.

PMID:
24566154
DOI:
10.1097/CEJ.0000000000000017
[Indexed for MEDLINE]
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