Send to

Choose Destination
See comment in PubMed Commons below
Science. 1988 Jul 29;241(4865):593-5.

Conversion of normal behavior to shiverer by myelin basic protein antisense cDNA in transgenic mice.

Author information

Department of DNA Biology, School of Medicine, Tokai University, Isehara, Japan.


Myelin basic proteins (MBPs) are coded by the single gene necessary for myelin formation in the central nervous system of the mouse. An antisense MBP mini-gene was constructed and used to determine the function of antisense DNA in transgenic mice. Several transgenic offspring of a founder transgenic mouse, AS100, were converted from the normal to mutant shiverer phenotype. Antisense MBP messenger RNA was expressed in these mice, and the endogenous MBP messenger RNA, the MBP, and the myelination in the central nervous system were reduced.

[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Support Center