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Environ Toxicol Pharmacol. 2014 Mar;37(2):513-20. doi: 10.1016/j.etap.2014.01.008. Epub 2014 Jan 22.

Anti-amyloidogenic effects of ID1201, the ethanolic extract of the fruits of Melia toosendan, through activation of the phosphatidylinositol 3-kinase/Akt pathway.

Author information

1
ILDONG Research Laboratories, ILDONG Pharmaceutical Co. Ltd., Hwaseong, Gyeonggi 445-710, Republic of Korea.
2
College of Pharmacy, Chungbuk National University, Cheongju 361-763, Republic of Korea.
3
Department of Biological Sciences, Konkuk University, 1 Hwayang-dong, Gwangjin-gu, Seoul 143-701, Republic of Korea.
4
ILDONG Research Laboratories, ILDONG Pharmaceutical Co. Ltd., Hwaseong, Gyeonggi 445-710, Republic of Korea. Electronic address: swyeon@ildong.com.

Abstract

Amyloid beta (Aβ) peptides, which are generated from amyloid precursor protein (APP), are thought to play a major role in the pathogenesis of Alzheimer's disease (AD). This study investigated the anti-amyloidogenic effects of the ethanolic extract of Meliae Fructus (ID1201) using human embryonic kidney 293 cells with stably expressed human wild-type or Swedish mutant APP695 and β-secretase 1. ID1201 treatment enhanced the non-amyloidogenic metabolism of APP; increases in soluble APPα levels and decreases in soluble APPβ and Aβ levels resulted from the α-secretase activation through the phosphatidylinositol 3-kinase (PI3K)/Akt pathway. In addition, ID1201-treated 5×familial AD (FAD) mice with 5 mutations in APP and presenilin 1 showed reduced levels of Aβ and amyloid plaques in the brain relative to those of 5×FAD mice with vehicle treatments. These results indicate that ID1201 possesses anti-amyloidogenic effects via the activation of the PI3K/Akt pathway, suggesting that it is a potential therapeutic agent for AD.

KEYWORDS:

Alzheimer's disease; Amyloid beta; Anti-amyloidogenic; ID1201; Meliae Fructus

PMID:
24566006
DOI:
10.1016/j.etap.2014.01.008
[Indexed for MEDLINE]
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