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Wei Sheng Yan Jiu. 2014 Jan;43(1):16-21.

[Effects of nano-selenium on cognition performance of mice exposed in 1800 MHz radiofrequency fields].

[Article in Chinese]

Author information

  • 1Department of Chemistry, Biology and Materials Engineering, Suzhou Science and Technology University, Suzhou 215009, China. qinfenju@mail.usts.edu.cn
  • 2Department of Chemistry, Biology and Materials Engineering, Suzhou Science and Technology University, Suzhou 215009, China.

Abstract

OBJECTIVE:

To study the effects of nano-selenium (NSe) on cognition performance of mice exposed to 1800 MHz radiofrequency fields (RF).

METHODS:

Male mice were randomly divided into four groups, control and nano-Se low, middle and high dose groups (L, M, H). Each group was sub-divided into three groups, RF 0 min, RF 30 min and RF 120 min. Nano-se solution (2, 4 and 8 microg/ml) were administered to mice of L, M, H groups by intra-gastric injection respectively, 0.5 ml/d for 50 days, the conctral group were administered with distilled water. At the 21st day, the mice in RF subgroup were exposed to 208 microW/cm2 1800 MHz radiofrequency fields (0, 30 and 120 min/d respectively) for 30 days. The cognitive ability of the mice were tested with Y-maze. Further, the levels of MDA, GABA, Glu, Ach and the activities of CAT and GSH-Px in cerebra were measured.

RESULTS:

Significant impairments in learning and memory (P < 0.05) were observed in the RF 120 min group, and with reduction of the Ach level and the activities of CAT and GSH-Px and increase of the content of GABA, Glu and MDA in cerebrum. NSe enhanced cognitive performance of RF mice, decreased GABA, Glu and MDA levels, increased Ach levels, GSH-Px and CAT activities.

CONCLUSION:

NSe could improve cognitive impairments of mice exposed to RF, the mechanism of which might involve the increasing antioxidation, decreasing free radical content and the changes of cerebra neurotransmitters.

PMID:
24564105
[PubMed - indexed for MEDLINE]
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