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J Child Neurol. 2014 Nov;29(11):1548-53. doi: 10.1177/0883073813520496. Epub 2014 Feb 20.

Extrapontine myelinolysis in an 18-month-old boy with diabetic ketoacidosis: case report and literature review.

Author information

1
Department of Child Neurology, Faculty of Medicine, Akdeniz University, Antalya, Turkey.
2
Department of Pediatric Intensive Care, Faculty of Medicine, Akdeniz University, Antalya, Turkey.
3
Department of Radiology, Faculty of Medicine, Akdeniz University, Antalya, Turkey.
4
Department of Pediatric Intensive Care, Faculty of Medicine, Akdeniz University, Antalya, Turkey oguzdursun@akdeniz.edu.tr.

Abstract

Extrapontine myelinolysis is characterized by symmetric demyelination following rapid shifts in serum osmolality in the supratentorial compartment. Extrapontine myelinolysis in children is rare compared to adults. The most common underlying pathophysiology is rapid correction of hyponatremia. Only 2 cases were published after diabetic ketoacidosis without electrolyte imbalance in the English literature. This study presents an unusual and possibly the youngest case of extrapontine myelinolysis that occurred in the setting of diabetic ketoacidosis and complicated cerebral edema without electrolyte imbalance, along with a review of the literature.

KEYWORDS:

children; diabetic ketoacidosis; extrapontine myelinolysis

PMID:
24563474
DOI:
10.1177/0883073813520496
[Indexed for MEDLINE]

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