Format

Send to

Choose Destination
See comment in PubMed Commons below
Eur Rev Med Pharmacol Sci. 2014;18(3):352-8.

Subclinical hypercortisol-assessment of bone fragility: experience of single osteoporosis center in Sicily.

Author information

1
Department of Internal Medicine, University of Messina, Italy. matteritano@unime.it.

Abstract

AIM:

Hypercortisolism is known to cause osteoporosis. Some evidence suggests that osteoporotic fractures may be the presenting manifestations of otherwise-asymptomatic hypercortisolism. The aim of our research was to investigate the prevalence of subclinical hypercortisolism (SH) in postmenopausal women evaluated for bone fragility.

PATIENTS AND METHODS:

One hundred consecutive postmenopausal women attending the Osteoporosis Centre in the Department of Internal Medicine of the University of Messina (Messina, Italy), for the first time, were screened and a total of 50 patients (age 58±5 years) were studied. Hypercortisolism was diagnosed by unsuppressed serum cortisol levels after 2 day low dose dexamethasone suppression test.

RESULTS:

Among the 50 postmenopausal women studied, 3 had SH. This prevalence was 6%. The three patients with SH had a normal bone mineral density (BMD) at lumbar spine and were osteopenic at femoral neck, and presented one or more vertebral fractures at spinal radiography.

CONCLUSIONS:

Physicians should always consider SH among the causes of bone fragility, especially in individuals with vertebral fractures and the presence of an only slightly reduced BMD.

PMID:
24563434
[Indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for European Review for Medical and Pharmacological Sciences
    Loading ...
    Support Center