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Doc Ophthalmol. 2014 Apr;128(2):121-9. doi: 10.1007/s10633-014-9429-y. Epub 2014 Feb 23.

Difficulties of motion-onset VEP interpretation in school-age children.

Author information

1
Department of Pathophysiology, Faculty of Medicine in Hradec Kralove, Charles University in Prague, Simkova 870, 500 38, Hradec Kralove, Czech Republic, kubova@lfhk.cuni.cz.

Abstract

BACKGROUND:

In adults, motion-onset visual evoked potentials (M-VEPs) with a dominant N2 peak represent a useful diagnostic tool. However, it is difficult to use this type of VEP in children because of the long maturation (up to 18 years) of M-VEPs, which is characterised by a gradual decrease in N2 peak latency and shape development. Moreover, in some children, M-VEPs are difficult to identify with standard stimuli.

METHODS:

We tested features of M-VEPs in 30 children (7-12 years) with the following set of standard stimuli used in our lab for examining adults ( https://web.lfhk.cuni.cz/elf ): low-contrast translation motion (TM) and expansion/contraction motion (ExCoM) in full field and in periphery (with central 20° masked). In 16 children, a high-contrast TM was also tested.

RESULTS:

With standard (low-contrast) stimuli, a common M-VEP to TM and to ExCoM was detected in 77 and 83 % of children, respectively. The M-VEPs to ExCoM in the periphery were detected in only 43 % of children. An abnormal dominant P1 peak was found in 9 % of VEPs to TM, 12 % of VEPs to full-field ExCoM and 14 % of VEPs to peripheral ExCoM. The M-VEPs to all low-contrast stimuli displayed large inter-individual latency variability (N2 peak latency differed for more than 100 ms). High contrast (more suitable for the non-mature magnocellular pathway) shortened M-VEP latencies and improved amplitudes.

CONCLUSIONS:

Our findings show that the maturation of motion perception in children is inter-individually variable, which limits the diagnostic use of M-VEPs.

PMID:
24563372
DOI:
10.1007/s10633-014-9429-y
[Indexed for MEDLINE]

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