Format

Send to

Choose Destination
See comment in PubMed Commons below
Cortex. 2014 Apr;53:9-26. doi: 10.1016/j.cortex.2014.01.001. Epub 2014 Jan 15.

Prediction in the service of comprehension: modulated early brain responses to omitted speech segments.

Author information

1
Institute of Psychology, University of Leipzig, Leipzig, Germany; Auditory Psychophysiology Lab, Department of Psychology, Cluster of Excellence "Hearing4all", European Medical School, Carl von Ossietzky University of Oldenburg, Oldenburg, Germany. Electronic address: alexandra.bendixen@uni-oldenburg.de.
2
Max Planck Research Group "Auditory Cognition", Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.

Abstract

Speech signals are often compromised by disruptions originating from external (e.g., masking noise) or internal (e.g., inaccurate articulation) sources. Speech comprehension thus entails detecting and replacing missing information based on predictive and restorative neural mechanisms. The present study targets predictive mechanisms by investigating the influence of a speech segment's predictability on early, modality-specific electrophysiological responses to this segment's omission. Predictability was manipulated in simple physical terms in a single-word framework (Experiment 1) or in more complex semantic terms in a sentence framework (Experiment 2). In both experiments, final consonants of the German words Lachs ([laks], salmon) or Latz ([lats], bib) were occasionally omitted, resulting in the syllable La ([la], no semantic meaning), while brain responses were measured with multi-channel electroencephalography (EEG). In both experiments, the occasional presentation of the fragment La elicited a larger omission response when the final speech segment had been predictable. The omission response occurred ∼125-165 msec after the expected onset of the final segment and showed characteristics of the omission mismatch negativity (MMN), with generators in auditory cortical areas. Suggestive of a general auditory predictive mechanism at work, this main observation was robust against varying source of predictive information or attentional allocation, differing between the two experiments. Source localization further suggested the omission response enhancement by predictability to emerge from left superior temporal gyrus and left angular gyrus in both experiments, with additional experiment-specific contributions. These results are consistent with the existence of predictive coding mechanisms in the central auditory system, and suggestive of the general predictive properties of the auditory system to support spoken word recognition.

KEYWORDS:

Auditory processing; Omission mismatch negativity (MMN); Predictive coding; Semantic expectation; Source localization

PMID:
24561233
DOI:
10.1016/j.cortex.2014.01.001
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center