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Cell. 2014 Feb 27;156(5):1072-83. doi: 10.1016/j.cell.2014.01.044. Epub 2014 Feb 20.

Neurogenesis in the striatum of the adult human brain.

Author information

1
Department of Cell and Molecular Biology, Karolinska Institute, 171 77 Stockholm, Sweden.
2
Department of Cell and Molecular Biology, Karolinska Institute, 171 77 Stockholm, Sweden; Department of Oncology-Pathology, Karolinska Institute, 171 77 Stockholm, Sweden.
3
Institut Camille Jordan, CNRS UMR 5208, University of Lyon, 69622 Villeurbanne, France.
4
Department of Physics and Astronomy, Ion Physics, Uppsala University, 751 20 Uppsala, Sweden.
5
NHLBI, NIH, Bethesda, Maryland 20892, USA.
6
Department of Oncology-Pathology, Karolinska Institute, 171 77 Stockholm, Sweden.
7
Department of Cell and Molecular Biology, Karolinska Institute, 171 77 Stockholm, Sweden. Electronic address: jonas.frisen@ki.se.

Abstract

In most mammals, neurons are added throughout life in the hippocampus and olfactory bulb. One area where neuroblasts that give rise to adult-born neurons are generated is the lateral ventricle wall of the brain. We show, using histological and carbon-14 dating approaches, that in adult humans new neurons integrate in the striatum, which is adjacent to this neurogenic niche. The neuronal turnover in the striatum appears restricted to interneurons, and postnatally generated striatal neurons are preferentially depleted in patients with Huntington's disease. Our findings demonstrate a unique pattern of neurogenesis in the adult human brain.

PMID:
24561062
DOI:
10.1016/j.cell.2014.01.044
[Indexed for MEDLINE]
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