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J Diabetes Complications. 2014 May-Jun;28(3):286-90. doi: 10.1016/j.jdiacomp.2014.01.003. Epub 2014 Jan 16.

Association of myocardial dysfunction with vitamin D deficiency in patients with type 2 diabetes mellitus.

Author information

1
Division of Cardiology, Department of Medicine, the University of Hong Kong, Queen Mary Hospital, Hong Kong, China.
2
Division of Cardiology, Department of Medicine, the University of Hong Kong, Queen Mary Hospital, Hong Kong, China; Research Centre of Heart, Brain, Hormone and Healthy Aging, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Hong Kong, China. Electronic address: hftse@hkucc.hku.hk.
3
Division of Cardiology, Department of Medicine, the University of Hong Kong, Queen Mary Hospital, Hong Kong, China; Research Centre of Heart, Brain, Hormone and Healthy Aging, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Hong Kong, China. Electronic address: khkyiu@hku.hk.

Abstract

AIMS:

The underlying mechanism of myocardial dysfunction in patients with type 2 diabetes mellitus (T2DM) is unclear. Nonetheless recent studies have revealed that vitamin D (vit-D) deficiency, which is prevalent in such patients, is associated with adverse cardiovascular events. We hypothesized that vit-D deficiency in patients with T2DM may contribute to left ventricular (LV) dysfunction.

METHODS:

We studied 95 patients (62±9years, 58% female) with T2DM. None had any history of coronary artery disease and all underwent detailed transthoracic echocardiography, including speckle tracking derived strains. Plasma level of 25-hydoxyvitamin D (25-OHD) was also measured.

RESULTS:

Vitamin D deficiency was evident in 60 (63%) patients. The LV dimension, LVEF and diastolic grade were similar between those with and without deficiency although an impaired global longitudinal strain was present in the former. Importantly, 25-OHD was negatively associated with global longitudinal strain (R = -0.21, P=0.046) and positively with body-mass index (BMI; R=0.26, P=0.01). Both vit-D deficiency and BMI were associated with impaired global LV longitudinal strain, independent of T2DM disease characteristics.

CONCLUSIONS:

In patients with T2DM and no history of coronary artery disease, vit-D deficiency is independently associated with impaired global longitudinal strain. This suggests that vit-D deficiency may contribute to the development of myocardial dysfunction in these patients.

KEYWORDS:

Diabetes Mellitus; Myocardial dysfunction; Vitamin D deficiency

PMID:
24560423
DOI:
10.1016/j.jdiacomp.2014.01.003
[Indexed for MEDLINE]

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