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Metabolism. 2014 Apr;63(4):441-51. doi: 10.1016/j.metabol.2014.01.006. Epub 2014 Jan 17.

The many roles of PGC-1α in muscle--recent developments.

Author information

1
Cardiovascular Institute and Center for Vascular Biology Research, Beth Israel Deaconess Medical Center and Harvard Medical School.
2
Cardiovascular Institute and Center for Vascular Biology Research, Beth Israel Deaconess Medical Center and Harvard Medical School. Electronic address: zarany@bidmc.harvard.edu.

Abstract

Skeletal muscle is the largest organ in the body and contributes to innumerable aspects of organismal biology. Muscle dysfunction engenders numerous diseases, including diabetes, cachexia, and sarcopenia. At the same time, skeletal muscle is also the main engine of exercise, one of the most efficacious interventions for prevention and treatment of a wide variety of diseases. The transcriptional coactivator PGC-1α has emerged as a key driver of metabolic programming in skeletal muscle, both in health and in disease. We review here the many aspects of PGC-1α function in skeletal muscle, with a focus on recent developments.

KEYWORDS:

Metabolism; Muscle; PGC-1alpha

PMID:
24559845
PMCID:
PMC4040247
DOI:
10.1016/j.metabol.2014.01.006
[Indexed for MEDLINE]
Free PMC Article

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