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Acta Paediatr Scand. 1988 Jul;77(4):619-22.

Neurologic sequelae following interferon therapy of juvenile laryngeal papilloma.

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Department of Paediatrics, Tampere University Central Hospital, Finland.


Human leukocyte interferon at doses from 2 million units every two days to 3 million units daily was given to a 2-year-old boy for the treatment of recurrent juvenile laryngeal papilloma. After 7 months of treatment the child developed spastic diplegia, which persisted despite the discontinuation of interferon therapy. The clinical picture was consistent with an upper motor neuron lesion; no evidence of peripheral neuropathy was found.

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