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Int J Mol Sci. 2014 Feb 19;15(2):2840-57. doi: 10.3390/ijms15022840.

Gram-negative flagella glycosylation.

Author information

1
Department of Microbiology, Faculty of Biology, University of Barcelona, Diagonal 643, Barcelona 08071, Spain. smerino@ub.edu.
2
Department of Microbiology, Faculty of Biology, University of Barcelona, Diagonal 643, Barcelona 08071, Spain. jtomas@ub.edu.

Abstract

Protein glycosylation had been considered as an eccentricity of a few bacteria. However, through advances in analytical methods and genome sequencing, it is now established that bacteria possess both N-linked and O-linked glycosylation pathways. Both glycosylation pathways can modify multiple proteins, flagellins from Archaea and Eubacteria being one of these. Flagella O-glycosylation has been demonstrated in many polar flagellins from Gram-negative bacteria and in only the Gram-positive genera Clostridium and Listeria. Furthermore, O-glycosylation has also been demonstrated in a limited number of lateral flagellins. In this work, we revised the current advances in flagellar glycosylation from Gram-negative bacteria, focusing on the structural diversity of glycans, the O-linked pathway and the biological function of flagella glycosylation.

PMID:
24557579
PMCID:
PMC3958885
DOI:
10.3390/ijms15022840
[Indexed for MEDLINE]
Free PMC Article

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