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Nat Rev Mol Cell Biol. 2014 Mar;15(3):155-62. doi: 10.1038/nrm3757.

Making new contacts: the mTOR network in metabolism and signalling crosstalk.

Author information

1
Biozentrum, University of Basel, Basel 4056, Switzerland.

Abstract

More than 20 years after its discovery, our understanding of target of rapamycin (TOR) signalling continues to grow. Recent global 'omics' studies have revealed physiological roles of mammalian TOR (mTOR) in protein, nucleotide and lipid synthesis. Furthermore, emerging evidence provides new insight into the control of mTOR by other pathways such as Hippo, WNT and Notch signalling. Together, this progress has expanded the list of downstream effectors and upstream regulators of mTOR signalling.

PMID:
24556838
DOI:
10.1038/nrm3757
[Indexed for MEDLINE]

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