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Dermatology. 2014;228(2):136-44. doi: 10.1159/000351557. Epub 2014 Feb 15.

Efficacy and safety of propranolol for the treatment of infantile hemangioma: a presentation of ninety-nine cases.

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Department of Dermatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.



Propranolol is highly effective in the treatment of infantile hemangioma (IH), but important clinical and pharmacological data are lacking.


The aims of the present study were to evaluate the efficacy of propranolol for the treatment of IH, to identify favorable prognostic factors in propranolol-treated IH, and to evaluate the safety of propranolol for the treatment of IH.


Clinical data were recorded from the electronic files and digital photographs of 99 patients with IH attending a tertiary pediatric medical center (2008-2011). Findings were evaluated by regression in volume and color changes.


The male-to-female ratio was 1:4. Age at treatment initiation was 9.4 ± 10.1 months; 15% of the treated hemangiomas were beyond the proliferative phase (17-54 months). The propranolol starting dose was 2 mg/kg/day. Duration of the treatment was 8.5 ± 3.2 months. All but 1 patient responded to treatment. A longer treatment course was required for segmental and deep hemangiomas. Mild side effects occurred in 32% of patients. Recurrence occurred in 13% of patients.


Lesions located on the face are better responders when treatment is started early. Treatment should continue up to age 12-15 months, with a longer course for segmental or deep hemangiomas.

[Indexed for MEDLINE]

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