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Oral Surg Oral Med Oral Pathol Oral Radiol. 2014 Apr;117(4):462-70. doi: 10.1016/j.oooo.2013.12.400. Epub 2013 Dec 20.

Lactobacillus salivarius WB21--containing tablets for the treatment of oral malodor: a double-blind, randomized, placebo-controlled crossover trial.

Author information

1
Section of General Dentistry, Department of General Dentistry, Fukuoka Dental College, Fukuoka, Japan. Electronic address: naojsz@college.fdcnet.ac.jp.
2
Center for Oral Diseases, Fukuoka Dental College, Fukuoka, Japan.
3
Tanabe Preservative Dentistry, Fukuoka, Japan.
4
Section of General Dentistry, Department of General Dentistry, Fukuoka Dental College, Fukuoka, Japan.

Abstract

OBJECTIVE:

This study evaluated the effect of probiotic intervention using lactobacilli on oral malodor.

STUDY DESIGN:

We conducted a 14-day, double-blind, placebo-controlled, randomized crossover trial of tablets containing Lactobacillus salivarius WB21 (2.0 × 10(9) colony-forming units per day) or placebo taken orally by patients with oral malodor.

RESULTS:

Organoleptic test scores significantly decreased in both the probiotic and placebo periods compared with the respective baseline scores (P < .001 and P = .002), and no difference was detected between periods. In contrast, the concentration of volatile sulfur compounds (VSCs) (P = .019) and the average probing pocket depth (P = .001) decreased significantly in the probiotic period compared with the placebo period. Bacterial quantitative analysis found significantly lower levels of ubiquitous bacteria (P = .003) and Fusobacterium nucleatum (P = .020) in the probiotic period.

CONCLUSIONS:

These results indicated that daily oral consumption of tablets containing probiotic lactobacilli could help to control oral malodor and malodor-related factors.

PMID:
24556493
DOI:
10.1016/j.oooo.2013.12.400
[Indexed for MEDLINE]

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