Format

Send to

Choose Destination
See comment in PubMed Commons below
Interv Neuroradiol. 2014 Jan-Feb;20(1):116-25. Epub 2014 Feb 10.

Angiogenesis in steno-occlusive vasculopathies as a common pathway for intracranial haemorrhage. A report of six cases.

Author information

1
Department of Radiology, Academic Medical Centre, University of Amsterdam; Amsterdam, The Netherlands - R.vdberg@amc.uva.nl.
2
Department of Neurosurgery, Radboud University Medical Centre; Nijmegen, The Netherlands.
3
Department of Radiology, Academic Medical Centre, University of Amsterdam; Amsterdam, The Netherlands.
4
Department of Radiology, VU Medical Centre; Amsterdam, The Netherlands.
5
Department of Neurology, Academic Medical Centre, University of Amsterdam; Amsterdam, The Netherlands.
6
Neurosurgical Centre Amsterdam, Academic Medical Centre, University of Amsterdam; Amsterdam, The Netherlands.

Abstract

Vasculopathies, including vasculitis of the central nervous system, can lead to stenosed, cicatrized vessels and the development of arterio-arteriolar collateral vessels. Bleeding due to these vascular changes, although rare, does occur. We describe six patients (all female, age range, 21-52 years; mean age, 42 years) with steno-occlusive lesions of intracranial vessels who presented with an acute intracranial haemorrhage. All had arterial steno-occlusive changes in conjunction with extensive leptomeningeal and arterio-arteriolar collaterals. Within the collaterals, focal dilatations could be identified, which were in close spatial relationship with the intracranial haemorrhage. Cause of bleeding was depicted on CT angiography in four out of six patients. One patient presented in childhood with acute stroke, one patient was diagnosed with Buerger's disease and one with sickle cell disease; the other three patients had no relevant history and the exact cause remained unclear. Outcome was favourable in all patients. Despite focal vascular weaknesses, no recurrent haemorrhage was seen during follow-up, supporting, at least in this small patient group, a conservative wait-and-see policy.

KEYWORDS:

angiography; angiopathy; intracranial haemorrhage

PMID:
24556309
PMCID:
PMC3971134
DOI:
10.15274/INR-2014-10017
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Atypon Icon for PubMed Central
    Loading ...
    Support Center