Format

Send to

Choose Destination
Curr Opin Genet Dev. 2014 Apr;25:50-61. doi: 10.1016/j.gde.2013.11.021. Epub 2014 Feb 17.

Genome regulation at the peripheral zone: lamina associated domains in development and disease.

Author information

1
Johns Hopkins University School of Medicine, Department of Biological Chemistry, Center for Epignetics, United States.
2
Johns Hopkins University School of Medicine, Department of Biological Chemistry, Center for Epignetics, United States. Electronic address: kreddy4@jhmi.edu.

Abstract

The nuclear periphery has been implicated in gene regulation and it has been proposed that proximity to the nuclear lamina and inner nuclear membrane (INM) leads to gene repression. More recently, it appears that there is a correlation and interdependence between lamina associated domains (LADs), the epigenome and overall three-dimensional architecture of the genome. However, the mechanisms of such organization at the 'peripheral zone' and the functional significance of these associations are poorly understood. The role these domains play in development and disease is an active and exciting area of research, expanding our knowledge of how the three-dimensional (3D) genome is regulated.

PMID:
24556270
DOI:
10.1016/j.gde.2013.11.021
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center