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J Neurol Sci. 2014 Apr 15;339(1-2):32-4. doi: 10.1016/j.jns.2014.01.044. Epub 2014 Feb 8.

Varicella zoster virus (VZV) in cerebral arteries of subjects at high risk for VZV reactivation.

Author information

1
Department of Neurology, University of Colorado School of Medicine, Aurora, CO, USA.
2
Department of Neurology, Columbia University Medical Center, New York, NY, USA.
3
Department of Neurology, University of Colorado School of Medicine, Aurora, CO, USA; Department of Microbiology, University of Colorado School of Medicine, Aurora, CO, USA. Electronic address: don.gilden@ucdenver.edu.

Abstract

With a decline in varicella zoster virus (VZV)-specific cell-mediated immunity, VZV can reactivate, infect cerebral arteries and cause stroke. Previous studies of cerebral arteries from subjects without a history of transient ischemic attacks or stroke revealed no VZV DNA or VZV antigen; however, VZV DNA and VZV antigen were found in the cerebral arteries of a subject with diabetes, a known risk factor for VZV reactivation and zoster. The present study analyzed an additional 55 cerebral arteries from 18 subjects with co-morbidities that may increase risk of VZV reactivation: a history of alcohol abuse, tricyclic antidepressant intoxication, cocaine abuse, HIV or being over age 70 years. VZV antigen was detected in 24 (44%) cerebral arteries from 14 (78%) subjects.

KEYWORDS:

Cerebral artery; Diabetes; Drug abuse; HIV; Subclinical reactivation; VZV

PMID:
24556269
PMCID:
PMC3978617
DOI:
10.1016/j.jns.2014.01.044
[Indexed for MEDLINE]
Free PMC Article
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