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Curr Opin Biotechnol. 2014 Aug;28:111-5. doi: 10.1016/j.copbio.2014.01.012. Epub 2014 Feb 17.

The future of whole-cell modeling.

Author information

1
Department of Bioengineering, Stanford University, Stanford, CA, USA.
2
Department of Chemical Engineering, Stanford University, Stanford, CA, USA.
3
Department of Bioengineering, Stanford University, Stanford, CA, USA. Electronic address: mcovert@stanford.edu.

Abstract

Integrated whole-cell modeling is poised to make a dramatic impact on molecular and systems biology, bioengineering, and medicine--once certain obstacles are overcome. From our group's experience building a whole-cell model of Mycoplasma genitalium, we identified several significant challenges to building models of more complex cells. Here we review and discuss these challenges in seven areas: first, experimental interrogation; second, data curation; third, model building and integration; fourth, accelerated computation; fifth, analysis and visualization; sixth, model validation; and seventh, collaboration and community development. Surmounting these challenges will require the cooperation of an interdisciplinary group of researchers to create increasingly sophisticated whole-cell models and make data, models, and simulations more accessible to the wider community.

PMID:
24556244
PMCID:
PMC4111988
DOI:
10.1016/j.copbio.2014.01.012
[Indexed for MEDLINE]
Free PMC Article
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