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Trends Genet. 2014 Mar;30(3):103-10. doi: 10.1016/j.tig.2014.01.002. Epub 2014 Feb 17.

HP1a: a structural chromosomal protein regulating transcription.

Author information

1
Edward A. Doisy Department of Biochemistry & Molecular Biology, Saint Louis University School of Medicine, Doisy Research Center, 1100 South Grand Boulevard, St Louis, MO 63104, USA.
2
Department of Biology, Washington University in St. Louis, Campus Box 1037, One Brookings Drive, St Louis, MO 63130-4899, USA. Electronic address: selgin@biology.wustl.edu.

Abstract

Heterochromatin protein 1 (HP1a in Drosophila) is a conserved eukaryotic chromosomal protein that is prominently associated with pericentric heterochromatin and mediates the concomitant gene silencing. Mechanistic studies implicate HP1 family proteins as 'hub proteins,' able to interact with a variety of chromosomal proteins through the chromo-shadow domain (CSD), as well as to recognize key histone modification sites [primarily histone H3 di/trimethyl Lys9 (H3K9me2/3)] through the chromodomain (CD). Consequently, HP1 has many important roles in chromatin architecture and impacts both gene expression and gene silencing, utilizing a variety of mechanisms. Clearly, HP1 function is altered by context, and potentially by post-translational modifications (PTMs). Here, we report on recent ideas as to how this versatile protein accomplishes its diverse functions.

KEYWORDS:

HP1a; chromodomain; gene expression; silencing

PMID:
24555990
PMCID:
PMC3991861
DOI:
10.1016/j.tig.2014.01.002
[Indexed for MEDLINE]
Free PMC Article

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