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Nat Prod Commun. 2013 Dec;8(12):1739-40.

Anti-allergic inflammatory effects of cyanogenic and phenolic glycosides from the seed of Prunus persica.

Author information

1
College of Pharmacy, Yeungnam University, Gyungsan, Gyungbuk, 712-749 Korea. jkim6923@knu.ac.kr
2
College of Pharmacy, Yeungnam University, Gyungsan, Gyungbuk, 712-749 Korea.
3
School of Medicine, Kyungpook National University, Daegu, 702-701 Korea.
4
College of Pharmacy, Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu, 702-701 Korea.

Abstract

A methanol extract of the seed of Prunus persica (Rosaceae) was found to inhibit histamine release in human mast cells. Activity-guided fractionation of the methanol extract yielded three cyanogenic glycosides (1-3) and other phenolic compounds (4-8). To evaluate their anti-allergic and anti-inflammatory activities, the isolates (1-8) were tested for their inhibitory effects on histamine release and on the gene expressions of tumor necrosis factor (TNF)-alpha and interleukin (IL)-6 in human mast cells. Of these, phenolic glycosides 7 and 8 suppressed histamine release and inhibited the pro-inflammatory cytokines TNF-alpha and IL-6. These results suggest that isolates from P. persica are among the anti-allergic inflammatory principles in this medicinal plant.

PMID:
24555287
[Indexed for MEDLINE]
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