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J Clin Microbiol. 2014 May;52(5):1720-3. doi: 10.1128/JCM.03308-13. Epub 2014 Feb 19.

Testing and genotyping of high-risk human papillomavirus by the cobas HPV Test and the Hybrid Capture 2 high-risk HPV DNA test using cervical and vaginal samples.

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1
ARUP Institute for Clinical and Experimental Pathology, Salt Lake City, Utah, USA.

Abstract

The accurate detection and typing of high-risk human papillomavirus (HPV) are critical for cervical cancer screening. The Hybrid Capture 2 (hc2) and cobas HPV tests showed high agreement for cervical samples (94.4%, κ=0.72, n=693) and moderate agreement for vaginal samples (κ=0.62, n=108). The HPV16 and HPV18 results were highly consistent between the cobas and Linear Array tests (κ≥0.96, n=197). Three hc2-negative vaginal samples were repeatedly invalid by the cobas test due to β-globin control failures, highlighting amplification control benefits. No cross-contamination was detected in a challenge experiment.

PMID:
24554756
PMCID:
PMC3993637
DOI:
10.1128/JCM.03308-13
[Indexed for MEDLINE]
Free PMC Article
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