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Arch Dis Child Fetal Neonatal Ed. 2014 Jul;99(4):F263-8. doi: 10.1136/archdischild-2013-304179. Epub 2014 Feb 19.

Outcomes of extremely low birthweight infants with acidosis at birth.

Author information

1
Division of Neonatology, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama, USA Department of Pediatrics, Rocky Mountain Hospital for Children, Denver, Colorado, USA.
2
Statistics and Epidemiology Unit, RTI International, Research Triangle Park, North Carolina, USA.
3
Division of Neonatology, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama, USA.
4
Department of Pediatrics, University of Iowa, Iowa City, Iowa, USA.
5
Department of Pediatrics, Stanford University, Palo Alto, California, USA.
6
Department of Pediatrics, Brown University, Providence, Rhode Island, USA.
7
Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.
8
Department of Pediatrics, Wayne State University, Detroit, Michigan, USA.
9
Pregnancy and Perinatology Branch, Eunice Kennedy Shriver National Institute of Child Health and Development (NICHD), Bethesda, Maryland, USA.

Abstract

OBJECTIVES:

To test the hypothesis that acidosis at birth is associated with the combined primary outcome of death or neurodevelopmental impairment (NDI) in extremely low birthweight (ELBW) infants, and to develop a predictive model of death/NDI exploring perinatal acidosis as a predictor variable.

STUDY DESIGN:

The study population consisted of ELBW infants born between 2002 and 2007 at National Institute of Child Health and Development (NICHD) Neonatal Research Network hospitals. Infants with cord blood gas data and documentation of either mortality prior to discharge or 18-22 month neurodevelopmental outcomes were included. Multiple logistic regression analysis was used to determine the contribution of perinatal acidosis, defined as a cord blood gas with a pH<7 or base excess (BE) <-12, to death/NDI in ELBW infants. In addition, a multivariable model predicting death/NDI was developed.

RESULTS:

3979 patients were identified of whom 249 had a cord gas pH<7 or BE<-12 mEq/L. 2124 patients (53%) had the primary outcome of death/NDI. After adjustment for confounding variables, pH<7 and BE<-12 mEq/L were each significantly associated with death/NDI (OR=2.5 (1.6, 4.2) and OR=1.5 (1.1, 2.0), respectively). However, inclusion of pH or BE did not improve the ability of the multivariable model to predict death/NDI.

CONCLUSIONS:

Perinatal acidosis is significantly associated with death/NDI in ELBW infants. Perinatal acidosis is infrequent in ELBW infants, however, and other factors are more important in predicting death/NDI.

KEYWORDS:

Neonatology; Neurodevelopment

Comment in

PMID:
24554564
PMCID:
PMC4274605
DOI:
10.1136/archdischild-2013-304179
[Indexed for MEDLINE]
Free PMC Article

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