Send to

Choose Destination
See comment in PubMed Commons below
Acta Derm Venereol. 1988;68(3):224-9.

Alterations of melatonin secretion in atopic eczema.

Author information

Department of Dermatology, University of Erlangen-Nuernberg, Federal Republic of Germany.


The circadian rhythm of melatonin secretion of the pineal gland can be disturbed in a variety of clinical conditions and diseases including some psychic disorders. To study the rhythmic behaviour of melatonin secretion in atopic eczema (AE), melatonin serum levels were measured every 2 h, starting at 8 a.m. in 18 patients suffering from severe AE. In 6 patients exhibiting low serum levels of melatonin, the circadian melatonin rhythm was found to be abolished. In 8 patients a diminished nocturnal melatonin increase was observed compared with the controls (n = 40). Only 4 patients showed a normal secretion pattern of melatonin. The results provide some evidence of a dysfunction of the pineal gland in AE, possibly due to a partially reduced activity of the sympathetic nervous system being involved in the control of melatonin secretion.

[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Loading ...
    Support Center