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Sci Rep. 2014 Feb 20;4:4143. doi: 10.1038/srep04143.

Serum Helicobacter pylori NapA antibody as a potential biomarker for gastric cancer.

Author information

1
1] Department of Epidemiology, College of Public Health, Harbin Medical University, Harbin, Heilongjiang Province, P. R. China [2].
2
1] Department of neurology, The forth affiliated hospital, Harbin Medical University, Harbin 150001, Heilongjiang Province, P. R. China [2].
3
Department of Epidemiology, College of Public Health, Harbin Medical University, Harbin, Heilongjiang Province, P. R. China.
4
Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, The University of Rhode Island, Pharmacy Building, 7 Greenhouse Road, Kingston, RI 02881, USA.
5
Department of Colorectal Cancer Surgery, The third affiliated hospital, Harbin Medical University, Harbin 150081, Heilongjiang Province, P. R. China.

Abstract

Helicobacter pylori (H. pylori) infection is strongly associated with gastric cancer. However, only a minority of infected individuals ever develop gastric cancer. This risk stratification may be in part due to differences among strains. The relationship between neutrophil-activating protein (NapA) and gastric cancer is unclear. The purpose of this study is to evaluate the significance of NapA as a biomarker in gastric cancer. We used enzyme linked immunosorbent assay (ELISA) to determine the status of H. pylori infection. Indirect ELISA method was used for detection of NapA antibody titer in the serum of H. pylori infected individuals. Unconditional logistic regressions were adopted to analyze the variables and determine the association of NapA and gastric cancer. The results of study indicated serum H. pylori NapA antibody level were associated with a reduced risk for development of gastric cancer. It may be used in conjugation with other indicators for gastric cancer detection.

PMID:
24553293
PMCID:
PMC3929916
DOI:
10.1038/srep04143
[Indexed for MEDLINE]
Free PMC Article
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