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Ann Hepatol. 2014 Mar-Apr;13(2):211-8.

Is recurrence rate of incidental hepatocellular carcinoma after liver transplantation similar to previously known HCC? towards a predictive recurrence score.

Author information

1
Hepatology and Liver Transplant Unit. Hospital Universitario Austral. Buenos Aires, Argentina.
2
Hepatology and Liver Transplant Unit. Hospital Italiano de Buenos Aires. Buenos Aires, Argentina.
3
Epidemiology and Statistics. Hospital Universitario Austral. Buenos Aires, Argentina.
4
Department of Pathology. Hospital Italiano de Buenos Aires. Buenos Aires, Argentina.

Abstract

BACKGROUND:

Incidental hepatocellular carcinoma (iHCC) generates uncertainty over risk of recurrence after liver transplantation (LT).

AIM:

To compare recurrence between iHCC and confirmed HCC diagnosed prior to transplant based on imaging criteria (cHCC).

MATERIAL AND METHODS:

Fifty-four HCC patients were analyzed from a series of 309 consecutive adult transplanted patients. We developed a recurrence predicting score (RPS) applying ORs based on pathologic risk variables.

RESULTS:

Incidence of iHCC was 4.8% (n = 15) and overall recurrence 12.9% (cHCC 15.4% and iHCC 7%; P = 0.39). Variables included in the RPS were: microvascular invasion OR 17.8 (1.78-178.97; P = 0.014: 2 points), neural invasion OR 15.5 (1.13-212.17; P = 0.04: 1.5 points), nuclear grade > II OR 9.3 (1.17-74.84; P = 0.035: 1 point), and beyond Up-to 7 criteria OR 13.1 (1.66-103.67; P = 0.015: 1.5 points). Two risk groups were identified: low risk for recurrence (0-1 point) and intermediate-high risk groups (2-6 points). Low risk category remained an independent predictor of recurrence: OR 0.11 (0.01-0.67; P = 0.017); AUROC of 0.75 (0.54-0.96). A tendency towards more patients categorized as low risk group among iHCC patients was observed (69.2%; P = 0.13).

CONCLUSIONS:

In this series iHCC was not associated to lower risk of recurrence when compared to cHCC. We propose application of an RPS as a clinical tool for recurrence risk estimation.

PMID:
24552863
[Indexed for MEDLINE]
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