Format

Send to

Choose Destination
Nutr Clin Pract. 2014 Apr;29(2):238-45. doi: 10.1177/0884533614522832. Epub 2014 Feb 19.

Study of body composition, lung function, and quality of life following use of anabolic steroids in patients with chronic obstructive pulmonary disease.

Author information

1
Mradul Kumar Daga, Department of Medicine, 129 B. L. Taneja Block, Maulana Azad Medical College, New Delhi, India. Email: drmraduldaga@gmail.com.

Abstract

BACKGROUND:

Chronic obstructive pulmonary disease (COPD) is characterized by irreversible airflow limitation and is associated with weight loss and decreased muscle strength and exercise capacity.

METHODS:

A double-blinded randomized controlled trial of 32 male COPD patients (age, 54.94 ± 11.27 years) was carried out to assess effects of anabolic steroid in terms of a daily high-protein, high-calorie diet alone or one combined with anabolic steroids on body composition, lung function, and health-related quality of life (HRQL). Outcomes were assessed by anthropometric and spirometric measurements, peak expiratory flow rate, partial pressure of oxygen in arterial blood, 6-minute walk test (6MWT), hand grip test, and HRQL index scores. Measurements were made at baseline and end of treatment (6 weeks).

RESULTS:

All patients showed significant difference (P < .001) in pulmonary function parameters and anthropometric measurements after 6 weeks of intervention (within-group changes); however, no significant improvement occurred in the pulmonary function parameters between the groups. The difference in exercise capacity (6MWT) and HRQL scores in the treatment group were statistically significant (P < .001) compared with control group after 6 weeks of intervention. In the treatment group, the average 6MWT distance increased from 213.5 m to 268.5 m at 6-week follow-up, and HRQL scores increased from 101.25 to 118.45. Also, HRQL and 6MWT parameters were positively correlated in response to steroid supplementation at the end of the study.

CONCLUSION:

Weekly administration of anabolic steroids during 6 weeks increased exercise capacity and quality of life in patients with COPD.

KEYWORDS:

anabolic agents; chronic obstructive pulmonary disease; nandrolone; nutrition; nutrition assessment

PMID:
24552826
DOI:
10.1177/0884533614522832
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center