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Nat Rev Neurosci. 2014 Mar;15(3):181-92. doi: 10.1038/nrn3677.

Hippocampal synaptic plasticity, spatial memory and anxiety.

Author information

1
Department of Experimental Psychology, University of Oxford, Oxford, OX1 3UD, UK.
2
Max Planck Institute for Medical Research, D-69120 Heidelberg, Germany.
3
Department of Psychology, Durham University, Durham, DH1 3LE, UK.
4
Department of Clinical Neurobiology, Medical Faculty of Heidelberg University and German Cancer Research Center (DKFZ), Heidelberg 69120, Germany.

Abstract

Recent studies using transgenic mice lacking NMDA receptors in the hippocampus challenge the long-standing hypothesis that hippocampal long-term potentiation-like mechanisms underlie the encoding and storage of associative long-term spatial memories. However, it may not be the synaptic plasticity-dependent memory hypothesis that is wrong; instead, it may be the role of the hippocampus that needs to be re-examined. We present an account of hippocampal function that explains its role in both memory and anxiety.

PMID:
24552786
DOI:
10.1038/nrn3677
[Indexed for MEDLINE]

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