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Br J Clin Pharmacol. 2015 Feb;79(2):208-15. doi: 10.1111/bcp.12356.

Targeting virulence not viability in the search for future antibacterials.

Author information

1
La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Vic.

Abstract

New antibacterials need new approaches to overcome the problem of rapid antibiotic resistance. Here we review the development of potential new antibacterial drugs that do not kill bacteria or inhibit their growth, but combat disease instead by targeting bacterial virulence.

KEYWORDS:

antibacterial; antivirulence; bacterial infection; pilicide; quorum sensing

PMID:
24552512
PMCID:
PMC4309627
DOI:
10.1111/bcp.12356
[Indexed for MEDLINE]
Free PMC Article

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