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ACS Chem Neurosci. 2014 Apr 16;5(4):253-60. doi: 10.1021/cn5000056. Epub 2014 Feb 27.

Classics in chemical neuroscience: diazepam (valium).

Author information

1
Department of Pharmacology, Johns Hopkins University , Baltimore, Maryland 21205, United States.

Abstract

Diazepam (Valium) is among the most successful drugs from the onset of the psychopharmacological revolution that began during the 1950s. Efficacious in treating a wide-spectrum of CNS disorders, including anxiety and epilepsy, it set the standard for pharmacotherapy in terms of potency, onset of action, and safety. In this Review, the legacy of diazepam to chemical neuroscience will be considered along with its synthesis, pharmacology, drug metabolism, adverse events and dependence, clinical use, and regulatory issues.

PMID:
24552479
PMCID:
PMC3990949
DOI:
10.1021/cn5000056
[Indexed for MEDLINE]
Free PMC Article

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