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AMIA Annu Symp Proc. 2013 Nov 16;2013:876-85. eCollection 2013.

Genetic variants improve breast cancer risk prediction on mammograms.

Author information

1
University of Wisconsin, Madison, WI, USA.
2
Marshfield Clinic Research Foundation, Marshfield, WI, USA.
3
Essentia Institute of Rural Health, Duluth, MN, USA.
4
Department of Hematology/Oncology, Marshfield Clinic Weston Center, Weston, WI, USA ; Marshfield Clinic Research Foundation, Marshfield, WI, USA ; School of Population Health, University of Queensland, Brisbane, Australia.

Abstract

Several recent genome-wide association studies have identified genetic variants associated with breast cancer. However, how much these genetic variants may help advance breast cancer risk prediction based on other clinical features, like mammographic findings, is unknown. We conducted a retrospective case-control study, collecting mammographic findings and high-frequency/low-penetrance genetic variants from an existing personalized medicine data repository. A Bayesian network was developed using Tree Augmented Naive Bayes (TAN) by training on the mammographic findings, with and without the 22 genetic variants collected. We analyzed the predictive performance using the area under the ROC curve, and found that the genetic variants significantly improved breast cancer risk prediction on mammograms. We also identified the interaction effect between the genetic variants and collected mammographic findings in an attempt to link genotype to mammographic phenotype to better understand disease patterns, mechanisms, and/or natural history.

PMID:
24551380
PMCID:
PMC3900221
[Indexed for MEDLINE]
Free PMC Article

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