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Proc Natl Acad Sci U S A. 2014 Mar 4;111(9):3502-7. doi: 10.1073/pnas.1401115111. Epub 2014 Feb 18.

Local immunostimulation leading to rejection of accepted male skin grafts by female mice as a model for cancer immunotherapy.

Author information

1
Ludwig Institute for Cancer Research, Brussels Branch, B-1200 Brussels, Belgium.

Abstract

Female mice of inbred strain CBA do not reject syngeneic male skin grafts even though they mount a T-cell response against the male-specific HY antigen. We show that local immunostimulation performed by injecting cytokines and Toll-like receptor ligands in close vicinity to the graft causes rejection. We feel that this approach should be tested in tumor-bearing human patients in combination with antitumor vaccination. Relief of intratumor immunosuppression may increase considerably the fraction of patients who respond to vaccination directed against tumor antigens recognized by T cells.

KEYWORDS:

immunology; transplantation

PMID:
24550491
PMCID:
PMC3948291
DOI:
10.1073/pnas.1401115111
[Indexed for MEDLINE]
Free PMC Article

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