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Br J Sports Med. 2015 Feb;49(4):255-8. doi: 10.1136/bjsports-2013-093014. Epub 2014 Feb 18.

Associations of overall sitting time and TV viewing time with fibrinogen and C reactive protein: the AusDiab study.

Author information

1
Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia School of Public Health & Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
2
Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia INSERM CESP U1018, Villejuif, France Univ Paris-Sud, UMRS 1018, Villlejuif, France.
3
Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia.
4
Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia School of Population Health, The University of Queensland, Brisbane, Queensland, Australia.
5
Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia School of Public Health & Preventive Medicine, Monash University, Melbourne, Victoria, Australia School of Population Health, The University of Queensland, Brisbane, Queensland, Australia School of Sport Science, Exercise & Health, University of Western Australia, Perth, Western Australia, Australia School of Exercise & Sports Science, Deakin University, Melbourne, Victoria, Australia.

Abstract

BACKGROUND/AIM:

Sedentary behaviour is associated with increased risk for all-cause and cardiovascular mortality. Plasma fibrinogen and C reactive protein (CRP)-key inflammatory and/or haemostatic markers-may contribute to this association; however, few studies have examined their relationships with sedentary behaviours. We examined associations of overall sitting and TV viewing time with fibrinogen and high-sensitivity CRP (hsCRP).

METHODS:

Plasma fibrinogen and hsCRP were measured in 3086 Australian adults (mean age: 55±12 years) who participated in the 2004-2005 AusDiab (Australian Diabetes, Obesity and Lifestyle) study. Multiple linear regression analyses examined cross-sectional associations of self-reported overall sitting and TV viewing time (h/day) with plasma fibrinogen and hsCRP, adjusting for sociodemographic, behavioural and medical treatments and conditions as potential covariates.

RESULTS:

Overall sitting time and TV viewing time were positively associated with plasma fibrinogen (sitting: β: 0.02 g/L, 95% CI (0.01 to 0.02); TV time: 0.03 g/L (0.02 to 0.05)) and hsCRP (sitting: 2.4% (1.2% to 3.6%); TV time: 4.5% (1.7% to 7.4%)). Associations were independent of leisure-time physical activity, but after adjusting for waist circumference, they remained for fibrinogen, but for hsCRP were attenuated to the null. Interactions were observed for gender×TV (p=0.011) with fibrinogen (associations in women only) and for waist circumference×TV (p=0.084) with hsCRP (associations in low-risk only).

CONCLUSIONS:

Overall sitting time was positively associated with plasma fibrinogen and hsCRP in men and women; associations of TV viewing time with fibrinogen were observed in women only. Abdominal adiposity-mediated associations for hsCRP but not for fibrinogen. Prospective and intervention studies are needed to establish likely causality and elucidate potential mechanisms.

PMID:
24550208
DOI:
10.1136/bjsports-2013-093014
[Indexed for MEDLINE]

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