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Adv Mater. 2014 May 28;26(20):3253-7. doi: 10.1002/adma.201304995. Epub 2014 Feb 18.

Developmentally-inspired shrink-wrap polymers for mechanical induction of tissue differentiation.

Author information

1
Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, 02115, USA; Harvard School of Engineering and Applied Sciences, Cambridge, MA, 02138, USA.

Abstract

A biologically inspired thermoresponsive polymer has been developed that mechanically induces tooth differentiation in vitro and in vivo by promoting mesenchymal cell compaction as seen in each pore of the scaffold. This normally occurs during the physiological mesenchymal condensation response that triggers tooth formation in the embryo.

KEYWORDS:

biomaterials; odontogenesis; poly(N-isopropylacrylamide); scaffold engineering; thermoresponsive

PMID:
24550068
PMCID:
PMC4146397
DOI:
10.1002/adma.201304995
[Indexed for MEDLINE]
Free PMC Article

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