Format

Send to

Choose Destination
Semin Immunol. 2014 Apr;26(2):127-31. doi: 10.1016/j.smim.2014.01.010. Epub 2014 Feb 16.

Tissue-resident natural killer cells and their potential diversity.

Author information

1
Rheumatology Division, Washington University School of Medicine, St. Louis, MO 63110, USA.
2
Department of Immunology, School of Life Sciences, University of Science and Technology of China, Hefei, Anhui, China; Hefei National Laboratory for Physical Sciences at Microscale, Hefei, Anhui, China.
3
Rheumatology Division, Washington University School of Medicine, St. Louis, MO 63110, USA; Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: yokoyama@dom.wustl.edu.

Abstract

Conventional NK cells are well characterized in the mouse spleen and circulate in the blood. Less well described are NK cells found in organs such as the liver, thymus, and uterus. Recently we identified a tissue-resident NK (trNK) cell population in the liver, suggesting a potential diversity of trNK cells in other organs. In this review we compare and contrast the similarities and differences among the subpopulations of NK and innate lymphoid cells to the trNK cells in the liver.

KEYWORDS:

Innate lymphoid-like cells; Liver; NK cells; Tissue-resident

PMID:
24548893
PMCID:
PMC4459495
DOI:
10.1016/j.smim.2014.01.010
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center