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Burns. 2014 Sep;40(6):1071-8. doi: 10.1016/j.burns.2014.01.013. Epub 2014 Feb 16.

Extracorporeal blood purification in burns: a review.

Author information

1
U.S. Army Institute of Surgical Research, Fort Sam Houston, San Antonio, TX 78234, United States. Electronic address: Katharina.Linden@ukb.uni-bonn.de.
2
San Antonio Military Medical Center, Fort Sam Houston, San Antonio, TX 78234, United States.
3
U.S. Army Institute of Surgical Research, Fort Sam Houston, San Antonio, TX 78234, United States.
4
San Antonio Military Medical Center, Fort Sam Houston, San Antonio, TX 78234, United States; Uniformed Services University of the Health Sciences, Bethesda, MD, 20814, United States.
5
U.S. Army Institute of Surgical Research, Fort Sam Houston, San Antonio, TX 78234, United States; University of Texas Health Science Center, San Antonio, TX 78229, United States.
6
U.S. Army Institute of Surgical Research, Fort Sam Houston, San Antonio, TX 78234, United States; Uniformed Services University of the Health Sciences, Bethesda, MD, 20814, United States.

Abstract

A prolonged and fulminant inflammatory state, with high levels of pro- and anti-inflammatory mediators, is seen after extensive thermal injury. Blood purification techniques including plasma exchange, continuous venovenous hemofiltration, and adsorbing membranes have the potential to modulate this response, thereby improving outcomes. This article describes the scientific rationale behind blood purification in burns and offers a review of literature regarding its potential application in this patient cohort.

KEYWORDS:

Blood purification; Burns; Cytokine removal; Thermal injury

PMID:
24548734
DOI:
10.1016/j.burns.2014.01.013
[Indexed for MEDLINE]
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