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Biochem Biophys Res Commun. 2014 Mar 21;445(4):739-45. doi: 10.1016/j.bbrc.2014.02.023. Epub 2014 Feb 15.

Analyzing protein-protein interactions in the post-interactomic era. Are we ready for the endgame?

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Institute of Molecular Genetics and Cell Biology, Department of Biology, Ulm University, James-Franck-Ring N27, D-89081 Ulm, Germany. Electronic address:


Mapping protein-protein interactions in genome-wide scales revealed thousands of novel binding partners in each of the explored model organisms. Organizing these hits in comprehensive ways is becoming increasingly important for systems biology approaches to understand complex cellular processes and diseases. However, proteome wide interaction techniques and their resulting global networks are not revealing the topologies of networks that are truly operating in the cell. In this short review I will discuss which prerequisites have to be fulfilled and which experimental methods might be practicable to translate primary protein interaction data into network presentations that help in understanding cellular processes.


Constraint interaction networks; Protein interaction; SPLIFF; Split-Ubiquitin

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