Format

Send to

Choose Destination
Paediatr Perinat Epidemiol. 2014 May;28(3):255-62. doi: 10.1111/ppe.12114. Epub 2014 Feb 18.

Identifying children with autism spectrum disorder at 18 months in a general population sample.

Author information

1
Norwegian Institute of Public Health, Oslo, Norway.

Abstract

BACKGROUND:

Previous research on clinical and high-risk samples suggests that signs of autism spectrum disorder (ASD) can be detected between 1 and 2 years of age. We investigated signs of ASD at 18 months in a population-based sample and the association with later ASD diagnosis.

METHODS:

The study sample includes 52,026 children born 2003 through 2008 and is a subset of children that participated in the Norwegian Mother and Child Cohort (MoBa), a population-based longitudinal study, and the Autism Birth Cohort (ABC), a sub-study on ASD. Parents completed all 23 items from the Modified Checklist for Autism in Toddlers (M-CHAT) at 18 months.

RESULTS:

The M-CHAT 6-critical-item criterion and the 23-item criterion had a specificity of 97.9% and 92.7% and a sensitivity of 20.8% and 34.1%, respectively. In the 173 children diagnosed with ASD to date, 60 children (34.7%) scored above the cut-off on either of the screening criteria. The items with the highest likelihood ratios were 'interest in other children', 'show objects to others' and 'response to name'.

CONCLUSION:

Even though one-third of the children who later received an ASD diagnosis were identified through M-CHAT items, the majority scored below cut-off on the screening criteria at 18 months. The results imply that it might not be possible to detect all children with ASD at this age.

KEYWORDS:

Autism Birth Cohort Study; M-CHAT; Norwegian Mother and Child Cohort Study; autism spectrum disorders; early identification; longitudinal studies

PMID:
24547686
PMCID:
PMC3976700
DOI:
10.1111/ppe.12114
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Wiley Icon for PubMed Central
Loading ...
Support Center