Format

Send to

Choose Destination
Biochem Biophys Res Commun. 1988 May 16;152(3):1263-8.

Amiloride increases the sensitivity of particulate guanylate cyclase to atrial natriuretic factor.

Author information

1
Labor für klinische Pharmakologie, Medizinische Klinik Innenstadt der Universität, München, FRG.

Abstract

The natriuretic agent amiloride induces a shift of the dose-response curve of particulate guanylate cyclase to atrial natriuretic factor (ANF) to the left. The ANF concentration for half-maximal activation of guanylate cyclase is shifted from 20 to 3 nM in the presence of 100 microM amiloride. This effect is observed with GTP*Mn2+, but not with GTP*Mg2+ as substrate. Amiloride derivatives, which inhibit a specific Na+-channel, also shift the dose-response curve to the left. These data suggest that some of the effects of amiloride may be mediated by an increased sensitivity of particulate guanylate cyclase to ANF.

PMID:
2454102
DOI:
10.1016/s0006-291x(88)80421-2
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center